kidney failure: An acute or chronic condition that is characterized by the inability of the kidneys to adequately filter the blood. [ NCIT:P378 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
18224 |
6. Filter based on genotype QC (FinnGen only) |
17525 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Renal failure
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 167529 | 73792 | 92048 |
| Only index persons | 136104 | 60579 | 75525 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.36 | 2.11 | 2.57 |
| Only index persons | 2.59 | 2.23 | 2.88 |
| Median age at first event (years) | |||
| Whole population | 76.09 | 79.57 | 73.34 |
| Only index persons | 76.22 | 79.93 | 73.24 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 17525 | 6181 | 11344 |
| Unadjusted period prevalence (%) | 4.54 | 2.43 | 5.70 |
| Median age at first event (years) | 71.43 | 70.64 | 71.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_RENFAIL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_RENFAIL | 3.616 [3.17, 4.12] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 27509 out of 48440 females with N14_RENFAIL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_RENFAIL | 3.583 [3.12, 4.11] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 33650 out of 62366 males with N14_RENFAIL died.
Mortality risk
Mortality risk for people of age
years, who have N14_RENFAIL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.255% | 0.505% |
| 5 | 1.717% | 3.317% |
| 10 | 4.238% | 7.747% |
| 15 | 7.989% | 13.969% |
| 20 | 13.114% | 22.27% |
Relationships between endpoints
↥Index endpoint: N14_RENFAIL – Renal failure
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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