No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
1325 |
4. Check minimum number of eventsNone |
1325 |
5. Include endpointsNone |
1325 |
6. Filter based on genotype QC (FinnGen only) |
1266 |
Control definitions (FinnGen only)
Control exclude
N14_RENFAIL
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Dialysis
based on the number of shared cases.
Similar with more cases:
- Dialysis
- Chronic kidney disease
- Renal failure
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7578 | 2775 | 4662 |
| Only index persons | 5007 | 1834 | 3173 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.08 | 0.13 |
| Only index persons | 0.10 | 0.07 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 58.04 | 56.95 | 58.56 |
| Only index persons | 56.33 | 54.78 | 57.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1266 | 479 | 787 |
| Unadjusted period prevalence (%) | 0.32 | 0.19 | 0.40 |
| Median age at first event (years) | 52.85 | 49.90 | 54.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_DIALYSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_DIALYSIS | 10.346 [8.64, 12.39] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.243 |
During the follow-up period (1.1.1998 — 31.12.2019), 928 out of 1839 females with N14_DIALYSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_DIALYSIS | 5.877 [5.05, 6.84] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.067 |
During the follow-up period (1.1.1998 — 31.12.2019), 1779 out of 3259 males with N14_DIALYSIS died.
Mortality risk
Mortality risk for people of age
years, who have N14_DIALYSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.795% | 1.139% |
| 5 | 5.745% | 7.242% |
| 10 | 14.281% | 16.771% |
| 15 | 24.757% | 29.518% |
| 20 | 39.322% | 45.548% |
Relationships between endpoints
↥Index endpoint: N14_DIALYSIS – Dialysis
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data