chronic kidney disease: Impairment of the renal function secondary to chronic kidney damage persisting for three or more months.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
11685 |
4. Check minimum number of eventsNone |
11685 |
5. Include endpoints |
11734 |
6. Filter based on genotype QC (FinnGen only) |
11265 |
Control definitions (FinnGen only)
Control exclude
N14_RENFAIL
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N17-N19
Name in latin
Insufficientia renalis chronica
Chronic kidney disease
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 99445 | 42581 | 55795 |
| Only index persons | 79681 | 34461 | 45220 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.41 | 1.22 | 1.56 |
| Only index persons | 1.53 | 1.27 | 1.73 |
| Median age at first event (years) | |||
| Whole population | 76.93 | 80.00 | 74.64 |
| Only index persons | 77.43 | 80.86 | 74.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 11265 | 3817 | 7448 |
| Unadjusted period prevalence (%) | 2.98 | 1.50 | 3.74 |
| Median age at first event (years) | 71.55 | 70.22 | 72.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_CHRONKIDNEYDIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_CHRONKIDNEYDIS | 3.61 [3.11, 4.18] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.02 |
During the follow-up period (1.1.1998 — 31.12.2019), 16749 out of 28850 females with N14_CHRONKIDNEYDIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_CHRONKIDNEYDIS | 3.418 [2.95, 3.96] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 22173 out of 39657 males with N14_CHRONKIDNEYDIS died.
Mortality risk
Mortality risk for people of age
years, who have N14_CHRONKIDNEYDIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.257% | 0.569% |
| 5 | 1.773% | 3.401% |
| 10 | 4.126% | 8.156% |
| 15 | 8.211% | 14.499% |
| 20 | 14.027% | 23.686% |
Relationships between endpoints
↥Index endpoint: N14_CHRONKIDNEYDIS – Chronic kidney disease
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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