kidney failure: An acute or chronic condition that is characterized by the inability of the kidneys to adequately filter the blood. [ NCIT:P378 ]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
7636 |
4. Check minimum number of eventsNone |
7636 |
5. Include endpointsNone |
7636 |
6. Filter based on genotype QC (FinnGen only) |
7360 |
Control definitions (FinnGen only)
Control exclude
N14_RENFAIL
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N17-N19
Name in latin
Insufficientia renalis acuta
Similar endpoints
↥List of similar endpoints to
Acute renal failure
based on the number of shared cases.
Similar with more cases:
- Renal failure
- Condition for Implicit Sepsis (Organ dysfunction codes)
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 70474 | 30883 | 38957 |
| Only index persons | 58723 | 25895 | 32828 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.00 | 0.88 | 1.09 |
| Only index persons | 1.12 | 0.95 | 1.25 |
| Median age at first event (years) | |||
| Whole population | 73.61 | 77.58 | 70.45 |
| Only index persons | 73.20 | 77.27 | 69.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7360 | 2675 | 4685 |
| Unadjusted period prevalence (%) | 1.88 | 1.05 | 2.35 |
| Median age at first event (years) | 70.26 | 70.22 | 70.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_ACUTERENFAIL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_ACUTERENFAIL | 3.889 [3.38, 4.47] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.202 |
During the follow-up period (1.1.1998 — 31.12.2019), 10354 out of 18924 females with N14_ACUTERENFAIL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_ACUTERENFAIL | 4.227 [3.62, 4.93] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 12503 out of 24431 males with N14_ACUTERENFAIL died.
Mortality risk
Mortality risk for people of age
years, who have N14_ACUTERENFAIL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.309% | 0.945% |
| 5 | 2.012% | 4.635% |
| 10 | 5.234% | 10.46% |
| 15 | 9.54% | 18.937% |
| 20 | 17.045% | 30.916% |
Relationships between endpoints
↥Index endpoint: N14_ACUTERENFAIL – Acute renal failure
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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