acute kidney tubular necrosis: Acute renal failure caused by the cell death of the renal tubules. Causes include nephrotoxins, cytotoxic drugs, and antibiotics.
Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
DOID EFO Endpoint Browser PheWeb
N14_DRUGSANDHEAVYMETAL
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
93 |
4. Check minimum number of eventsNone |
93 |
5. Include endpointsNone |
93 |
6. Filter based on genotype QC (FinnGen only) |
90 |
Control definitions (FinnGen only)
Control exclude
N14_RENALTUB
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N10-N16
Name in latin
Condiciones tubulo-interstitiales et tubulares ex medicamentis et metallis gravibus
Similar endpoints
↥List of similar endpoints to
Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
based on the number of shared cases.
Similar with more cases:
- Renal tubulo-interstitial diseases
- Genitourinary diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 684 | 289 | 389 |
| Only index persons | 549 | 241 | 308 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 64.13 | 65.48 | 62.95 |
| Only index persons | 62.02 | 64.29 | 60.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 90 | 36 | 54 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.03 |
| Median age at first event (years) | 56.61 | 58.18 | 55.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint N14_DRUGSANDHEAVYMETAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_DRUGSANDHEAVYMETAL | 3.362 [2.25, 5.03] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.349 |
During the follow-up period (1.1.1998 — 31.12.2019), 99 out of 233 females with N14_DRUGSANDHEAVYMETAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_DRUGSANDHEAVYMETAL | 3.426 [2.35, 4.99] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 306 males with N14_DRUGSANDHEAVYMETAL died.
Mortality risk
Mortality risk for people of age
years, who have N14_DRUGSANDHEAVYMETAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.39% | 0.579% |
| 5 | 1.968% | 3.236% |
| 10 | 4.881% | 8.516% |
| 15 | 9.146% | 16.055% |
| 20 | 15.779% | 26.508% |
Relationships between endpoints
↥Index endpoint: N14_DRUGSANDHEAVYMETAL – Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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