No definition available.
Nephropathy induced by other drugs, medicaments and biological substances
NEPHROP_INDUCED_OTHER_DRUGS_MEDICAM_BIOLO_SUBST
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
53 |
4. Check minimum number of eventsNone |
53 |
5. Include endpointsNone |
53 |
6. Filter based on genotype QC (FinnGen only) |
51 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Nephropathy induced by other drugs, medicaments and biological substances
based on the number of shared cases.
Similar with more cases:
- Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
- Renal tubulo-interstitial diseases
- Genitourinary diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 334 | 136 | 196 |
| Only index persons | 289 | 121 | 168 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.01 |
| Only index persons | 0.01 | 0.00 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 63.70 | 64.51 | 62.94 |
| Only index persons | 62.17 | 64.29 | 60.64 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 51 | 19 | 32 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | 55.85 | 57.58 | 54.82 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint NEPHROP_INDUCED_OTHER_DRUGS_MEDICAM_BIOLO_SUBST and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| NEPHROP_INDUCED_OTHER_DRUGS_MEDICAM_BIOLO_SUBST | 4.17 [2.8, 6.2] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 76 out of 162 males with NEPHROP_INDUCED_OTHER_DRUGS_MEDICAM_BIOLO_SUBST died.
Mortality risk
Mortality risk for people of age
years, who have NEPHROP_INDUCED_OTHER_DRUGS_MEDICAM_BIOLO_SUBST.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.833% |
| 5 | No data | 4.413% |
| 10 | No data | 10.621% |
| 15 | No data | 18.911% |
| 20 | No data | 30.656% |
Relationships between endpoints
↥Index endpoint: NEPHROP_INDUCED_OTHER_DRUGS_MEDICAM_BIOLO_SUBST – Nephropathy induced by other drugs, medicaments and biological substances
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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