pyelonephritis: Inflammation of the KIDNEY involving the renal parenchyma (the NEPHRONS); KIDNEY PELVIS; and KIDNEY CALICES. It is characterized by ABDOMINAL PAIN; FEVER; NAUSEA; VOMITING; and occasionally DIARRHEA.
Renal tubulo-interstitial disorders in diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
N14_RENALTUBULOINOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
304 |
4. Check minimum number of eventsNone |
304 |
5. Include endpointsNone |
304 |
6. Filter based on genotype QC (FinnGen only) |
287 |
Control definitions (FinnGen only)
Control exclude
N14_RENALTUB
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Renal tubulo-interstitial disorders in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Renal tubulo-interstitial diseases
- Genitourinary diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1856 | 880 | 962 |
| Only index persons | 1584 | 749 | 835 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 62.48 | 63.34 | 61.63 |
| Only index persons | 62.08 | 62.77 | 61.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 287 | 140 | 147 |
| Unadjusted period prevalence (%) | 0.06 | 0.05 | 0.07 |
| Median age at first event (years) | 59.26 | 57.23 | 61.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint N14_RENALTUBULOINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_RENALTUBULOINOTH | 2.925 [2.31, 3.71] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.263 |
During the follow-up period (1.1.1998 — 31.12.2019), 286 out of 748 females with N14_RENALTUBULOINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_RENALTUBULOINOTH | 2.812 [2.18, 3.63] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 319 out of 809 males with N14_RENALTUBULOINOTH died.
Mortality risk
Mortality risk for people of age
years, who have N14_RENALTUBULOINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.25% | 0.476% |
| 5 | 1.735% | 2.944% |
| 10 | 4.3% | 7.322% |
| 15 | 8.306% | 13.33% |
| 20 | 14.035% | 21.922% |
Relationships between endpoints
↥Index endpoint: N14_RENALTUBULOINOTH – Renal tubulo-interstitial disorders in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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