No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
20538 |
4. Check minimum number of eventsNone |
20538 |
5. Include endpoints |
21945 |
6. Filter based on genotype QC (FinnGen only) |
21047 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Disorders of skin appendages
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 193805 | 101378 | 91472 |
| Only index persons | 183504 | 97227 | 86277 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.73 | 2.90 | 2.56 |
| Only index persons | 3.44 | 3.57 | 3.29 |
| Median age at first event (years) | |||
| Whole population | 35.02 | 38.23 | 31.43 |
| Only index persons | 34.72 | 38.11 | 30.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 21047 | 13037 | 8010 |
| Unadjusted period prevalence (%) | 4.70 | 5.12 | 4.02 |
| Median age at first event (years) | 45.96 | 44.02 | 49.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_DISORDSKINAPPENDIX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_DISORDSKINAPPENDIX | 1.177 [1.07, 1.29] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.204 |
During the follow-up period (1.1.1998 — 31.12.2019), 5479 out of 70350 females with L12_DISORDSKINAPPENDIX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_DISORDSKINAPPENDIX | 1.373 [1.25, 1.51] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 6935 out of 64572 males with L12_DISORDSKINAPPENDIX died.
Mortality risk
Mortality risk for people of age
years, who have L12_DISORDSKINAPPENDIX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | 0.273% |
| 5 | 0.739% | 1.611% |
| 10 | 1.718% | 3.918% |
| 15 | 3.406% | 7.237% |
| 20 | 5.931% | 12.181% |
Relationships between endpoints
↥Index endpoint: L12_DISORDSKINAPPENDIX – Disorders of skin appendages
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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