Alopecia areata

L12_ALOPECAREATA

alopecia areata: Loss of scalp and body hair involving microscopically inflammatory patchy areas.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L63
  • Hospital discharge: ICD-9 7040B|7040C
  • Hospital discharge: ICD-8 70400
  • Cause of death: ICD-10 L63
  • Cause of death: ICD-9 7040B|7040C
  • Cause of death: ICD-8 70400

2 out of 7 registries used, show all original rules.

909

4. Check minimum number of events

None

909

5. Include endpoints

None

909

6. Filter based on genotype QC (FinnGen only)

862

Control definitions (FinnGen only)

Control exclude L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L60-L75
Name in latin Alopecia areata

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7560 5187 2341
Only index persons 7028 4903 2125
Unadjusted period prevalence (%)
Whole population 0.12 0.15 0.07
Only index persons 0.15 0.18 0.08
Median age at first event (years)
Whole population 32.57 36.09 24.73
Only index persons 33.86 37.07 26.45

-FinnGen-

Key figures

All Female Male
Number of individuals 862 673 189
Unadjusted period prevalence (%) 0.23 0.26 0.09
Median age at first event (years) 44.34 44.24 44.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint L12_ALOPECAREATA and mortality.

Females

Parameter HR [95% CI] p-value
L12_ALOPECAREATA 1.002 [0.85, 1.18] 0.981
Birth year 0.996 [0.99, 1.0] 0.338

During the follow-up period (1.1.1998 — 31.12.2019), 192 out of 4322 females with L12_ALOPECAREATA died.

Males

Parameter HR [95% CI] p-value
L12_ALOPECAREATA 0.868 [0.7, 1.08] 0.206
Birth year 0.987 [0.98, 1.0] 0.007

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 1847 males with L12_ALOPECAREATA died.

Mortality risk

Mortality risk for people of age

years, who have L12_ALOPECAREATA.

N-year risk Females Males
1 0.093% 0.179%
5 0.573% 1.007%
10 1.445% 2.59%
15 2.937% 4.999%
20 5.217% 8.461%

Relationships between endpoints

Index endpoint: L12_ALOPECAREATA – Alopecia areata

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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