acne: An inflammatory process of the sebaceous glands which is characterized by comedones, nodules, papules and/or pustules on the skin.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3920 |
4. Check minimum number of eventsNone |
3920 |
5. Include endpoints |
4192 |
6. Filter based on genotype QC (FinnGen only) |
3982 |
Control definitions (FinnGen only)
Control exclude
L12_DISORDSKINAPPENDIX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L60-L75
Name in latin
Acne
Similar endpoints
↥List of similar endpoints to
Acne
based on the number of shared cases.
Similar with more cases:
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 52364 | 25973 | 26178 |
| Only index persons | 51216 | 25574 | 25642 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.74 | 0.74 | 0.73 |
| Only index persons | 0.96 | 0.94 | 0.98 |
| Median age at first event (years) | |||
| Whole population | 20.29 | 21.46 | 19.05 |
| Only index persons | 20.23 | 21.46 | 19.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3982 | 2574 | 1408 |
| Unadjusted period prevalence (%) | 0.90 | 1.01 | 0.71 |
| Median age at first event (years) | 24.37 | 26.55 | 20.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_ACNE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACNE | 2.128 [1.75, 2.59] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.347 |
During the follow-up period (1.1.1998 — 31.12.2019), 306 out of 13469 females with L12_ACNE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ACNE | 1.88 [1.62, 2.18] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 599 out of 16909 males with L12_ACNE died.
Mortality risk
Mortality risk for people of age
years, who have L12_ACNE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.146% | 0.335% |
| 5 | 1.172% | 2.19% |
| 10 | 3.024% | 5.676% |
| 15 | 6.046% | 10.808% |
| 20 | 10.594% | 18.722% |
Relationships between endpoints
↥Index endpoint: L12_ACNE – Acne
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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