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Other and unspecified acne

DOID EFO Endpoint Browser PheWeb

L12_ACNE_NAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L70.8, L70.9
  • Hospital discharge: ICD-9 — 7061
  • Hospital discharge: ICD-8 — 70600|70612
  • Hospital discharge: excluded ICD-9 — 7061A|7061D|7061E
  • Cause of death: ICD-10 — L70.8, L70.9
  • Cause of death: ICD-9 — 7061
  • Cause of death: ICD-8 — 70600|70612
  • Cause of death: excluded ICD-9 — 7061A|7061D|7061E

2 out of 7 registries used, show all original rules.

462

4. Check minimum number of events

None

462

5. Include endpoints

None

462

6. Filter based on genotype QC (FinnGen only)

446

Control definitions (FinnGen only)

Control exclude L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4278 2091 2170
Only index persons 4081 2024 2057
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.06
Only index persons 0.08 0.07 0.08
Median age at first event (years)
Whole population 23.04 26.01 20.09
Only index persons 22.92 25.91 19.98

-FinnGen-

Key figures

All Female Male
Number of individuals 446 270 176
Unadjusted period prevalence (%) 0.10 0.11 0.09
Median age at first event (years) 26.80 28.15 24.73

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint L12_ACNE_NAS and mortality.

Females

Parameter HR [95% CI] p-value
L12_ACNE_NAS 1.745 [1.23, 2.48] 0.002
Birth year 1.001 [0.99, 1.01] 0.806

During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 1370 females with L12_ACNE_NAS died.

Males

Parameter HR [95% CI] p-value
L12_ACNE_NAS 2.269 [1.71, 3.0] < 0.001
Birth year 0.988 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 1383 males with L12_ACNE_NAS died.

Mortality risk

Mortality risk for people of age

years, who have L12_ACNE_NAS.

N-year risk Females Males
1 0.213% 0.453%
5 1.239% 2.551%
10 3.12% 6.449%
15 5.814% 12.242%
20 11.313% 20.698%

Relationships between endpoints

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Index endpoint: L12_ACNE_NAS – Other and unspecified acne

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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