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Acne varioliformis

DOID EFO Endpoint Browser PheWeb

L12_ACNE_VARIOLIFORMIS

acne: An inflammatory process of the sebaceous glands which is characterized by comedones, nodules, papules and/or pustules on the skin.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L70.2
  • Hospital discharge: ICD-9 — 7060A
  • Hospital discharge: ICD-8 — 70601
  • Cause of death: ICD-10 — L70.2
  • Cause of death: ICD-9 — 7060A
  • Cause of death: ICD-8 — 70601

2 out of 7 registries used, show all original rules.

85

4. Check minimum number of events

None

85

5. Include endpoints

None

85

6. Filter based on genotype QC (FinnGen only)

83

Control definitions (FinnGen only)

Control exclude L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L70
Name in latin Acne varioliformis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 575 296 276
Only index persons 520 275 245
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 54.38 52.45 56.29
Only index persons 51.46 50.11 52.97

-FinnGen-

Key figures

All Female Male
Number of individuals 83 48 35
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 52.31 47.48 58.93

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint L12_ACNE_VARIOLIFORMIS and mortality.

Females

Parameter HR [95% CI] p-value
L12_ACNE_VARIOLIFORMIS 3.159 [1.69, 5.9] < 0.001
Birth year 0.994 [0.99, 1.0] 0.158

During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 248 females with L12_ACNE_VARIOLIFORMIS died.

Males

Parameter HR [95% CI] p-value
L12_ACNE_VARIOLIFORMIS 2.79 [1.74, 4.47] < 0.001
Birth year 0.985 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 222 males with L12_ACNE_VARIOLIFORMIS died.

Mortality risk

Mortality risk for people of age

years, who have L12_ACNE_VARIOLIFORMIS.

N-year risk Females Males
1 0.295% 0.545%
5 1.815% 3.121%
10 4.642% 7.312%
15 8.799% 13.825%
20 14.855% 22.752%

Relationships between endpoints

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Index endpoint: L12_ACNE_VARIOLIFORMIS – Acne varioliformis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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