No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2649 |
4. Check minimum number of eventsNone |
2649 |
5. Include endpoints |
2977 |
6. Filter based on genotype QC (FinnGen only) |
2859 |
Control definitions (FinnGen only)
Control exclude
L12_DISORDSKINAPPENDIX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Nail disorders
based on the number of shared cases.
Similar with more cases:
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 26337 | 12260 | 13953 |
| Only index persons | 24048 | 11147 | 12901 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.37 | 0.35 | 0.39 |
| Only index persons | 0.45 | 0.41 | 0.49 |
| Median age at first event (years) | |||
| Whole population | 34.73 | 49.95 | 21.25 |
| Only index persons | 34.27 | 49.25 | 21.33 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2859 | 1634 | 1225 |
| Unadjusted period prevalence (%) | 0.63 | 0.64 | 0.62 |
| Median age at first event (years) | 47.64 | 51.64 | 42.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint L12_NAILDIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAILDIS | 1.572 [1.4, 1.77] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.082 |
During the follow-up period (1.1.1998 — 31.12.2019), 1243 out of 8957 females with L12_NAILDIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAILDIS | 1.596 [1.39, 1.83] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.024 |
During the follow-up period (1.1.1998 — 31.12.2019), 1109 out of 8967 males with L12_NAILDIS died.
Mortality risk
Mortality risk for people of age
years, who have L12_NAILDIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.161% | 0.331% |
| 5 | 0.798% | 2.091% |
| 10 | 2.111% | 5.359% |
| 15 | 4.118% | 9.648% |
| 20 | 7.309% | 16.305% |
Relationships between endpoints
↥Index endpoint: L12_NAILDIS – Nail disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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