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Other and unspecified nail disorders

DOID EFO Endpoint Browser PheWeb

L12_NAILNAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L60.8, L60.9
  • Hospital discharge: ICD-9 — 7038E|7038G|7038X|7039
  • Hospital discharge: ICD-8 — 70301|7030[8-9]
  • Cause of death: ICD-10 — L60.8, L60.9
  • Cause of death: ICD-9 — 7038E|7038G|7038X|7039
  • Cause of death: ICD-8 — 70301|7030[8-9]

2 out of 7 registries used, show all original rules.

642

4. Check minimum number of events

None

642

5. Include endpoints

None

642

6. Filter based on genotype QC (FinnGen only)

618

Control definitions (FinnGen only)

Control exclude L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4733 2702 2009
Only index persons 4307 2489 1818
Unadjusted period prevalence (%)
Whole population 0.07 0.08 0.06
Only index persons 0.08 0.09 0.07
Median age at first event (years)
Whole population 51.51 52.58 50.15
Only index persons 52.27 53.11 51.12

-FinnGen-

Key figures

All Female Male
Number of individuals 618 404 214
Unadjusted period prevalence (%) 0.14 0.16 0.11
Median age at first event (years) 58.02 57.38 59.23

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint L12_NAILNAS and mortality.

Females

Parameter HR [95% CI] p-value
L12_NAILNAS 1.733 [1.42, 2.12] < 0.001
Birth year 0.994 [0.99, 1.0] 0.162

During the follow-up period (1.1.1998 — 31.12.2019), 226 out of 1906 females with L12_NAILNAS died.

Males

Parameter HR [95% CI] p-value
L12_NAILNAS 2.137 [1.7, 2.68] < 0.001
Birth year 0.988 [0.98, 1.0] 0.012

During the follow-up period (1.1.1998 — 31.12.2019), 258 out of 1445 males with L12_NAILNAS died.

Mortality risk

Mortality risk for people of age

years, who have L12_NAILNAS.

N-year risk Females Males
1 0.197% 0.395%
5 1.018% 2.492%
10 2.49% 6.655%
15 4.702% 11.997%
20 8.331% 19.587%

Relationships between endpoints

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Index endpoint: L12_NAILNAS – Other and unspecified nail disorders

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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