No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
203 |
4. Check minimum number of eventsNone |
203 |
5. Include endpointsNone |
203 |
6. Filter based on genotype QC (FinnGen only) |
198 |
Control definitions (FinnGen only)
Control exclude
L12_DISORDSKINAPPENDIX
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L60
Name in latin
Dystrophia unguium
Similar endpoints
↥List of similar endpoints to
Nail dystrophy
based on the number of shared cases.
Similar with more cases:
- Nail disorders
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1588 | 915 | 667 |
| Only index persons | 1462 | 851 | 611 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 45.42 | 50.45 | 38.41 |
| Only index persons | 45.88 | 50.41 | 39.58 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 198 | 118 | 80 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | 52.59 | 53.02 | 51.95 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint L12_NAIL_DYSTROPHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAIL_DYSTROPHY | 1.491 [1.13, 1.97] | 0.005 |
| Birth year | 0.99 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 782 females with L12_NAIL_DYSTROPHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAIL_DYSTROPHY | 1.187 [0.87, 1.62] | 0.285 |
| Birth year | 0.988 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 524 males with L12_NAIL_DYSTROPHY died.
Mortality risk
Mortality risk for people of age
years, who have L12_NAIL_DYSTROPHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.129% | 0.238% |
| 5 | 0.734% | 1.34% |
| 10 | 1.892% | 3.472% |
| 15 | 3.565% | 6.6% |
| 20 | 6.123% | 11.305% |
Relationships between endpoints
↥Index endpoint: L12_NAIL_DYSTROPHY – Nail dystrophy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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