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Onychogryphosis

DOID Endpoint Browser PheWeb

L12_NAIL_GRYPHOSIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L60.2
  • Hospital discharge: ICD-9 — 7038C
  • Hospital discharge: ICD-8 — 70305
  • Cause of death: ICD-10 — L60.2
  • Cause of death: ICD-9 — 7038C
  • Cause of death: ICD-8 — 70305

2 out of 7 registries used, show all original rules.

84

4. Check minimum number of events

None

84

5. Include endpoints

None

84

6. Filter based on genotype QC (FinnGen only)

82

Control definitions (FinnGen only)

Control exclude L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L60
Name in latin Onychogryposis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1009 654 347
Only index persons 760 483 277
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.01
Median age at first event (years)
Whole population 55.13 56.57 52.13
Only index persons 52.59 53.62 50.79

-FinnGen-

Key figures

All Female Male
Number of individuals 82 53 29
Unadjusted period prevalence (%) 0.02 0.02 0.01
Median age at first event (years) 48.83 48.12 50.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint L12_NAIL_GRYPHOSIS and mortality.

Females

Parameter HR [95% CI] p-value
L12_NAIL_GRYPHOSIS 1.729 [1.08, 2.77] 0.023
Birth year 0.996 [0.99, 1.0] 0.325

During the follow-up period (1.1.1998 — 31.12.2019), 85 out of 308 females with L12_NAIL_GRYPHOSIS died.

Males

Parameter HR [95% CI] p-value
L12_NAIL_GRYPHOSIS 1.993 [1.26, 3.15] 0.003
Birth year 0.984 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 60 out of 199 males with L12_NAIL_GRYPHOSIS died.

Mortality risk

Mortality risk for people of age

years, who have L12_NAIL_GRYPHOSIS.

N-year risk Females Males
1 0.15% 0.353%
5 0.942% 2.183%
10 2.462% 5.526%
15 4.902% 10.297%
20 8.73% 16.677%

Relationships between endpoints

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Index endpoint: L12_NAIL_GRYPHOSIS – Onychogryphosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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