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Ingrowing nail

EFO MESH Endpoint Browser PheWeb

L12_NAIL_INGROW

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L60.0
  • Hospital discharge: ICD-9 — 7030A
  • Hospital discharge: ICD-8 — 70302
  • Cause of death: ICD-10 — L60.0
  • Cause of death: ICD-9 — 7030A
  • Cause of death: ICD-8 — 70302

2 out of 7 registries used, show all original rules.

1928

4. Check minimum number of events

None

1928

5. Include endpoints

None

1928

6. Filter based on genotype QC (FinnGen only)

1845

Control definitions (FinnGen only)

Control exclude L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L60
Name in latin Unguis incarnatus

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17737 7233 10429
Only index persons 16406 6643 9763
Unadjusted period prevalence (%)
Whole population 0.26 0.21 0.29
Only index persons 0.32 0.24 0.37
Median age at first event (years)
Whole population 31.79 48.16 20.32
Only index persons 30.95 46.59 20.32

-FinnGen-

Key figures

All Female Male
Number of individuals 1845 977 868
Unadjusted period prevalence (%) 0.41 0.38 0.44
Median age at first event (years) 40.77 48.83 31.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint L12_NAIL_INGROW and mortality.

Females

Parameter HR [95% CI] p-value
L12_NAIL_INGROW 1.527 [1.36, 1.72] < 0.001
Birth year 0.996 [0.99, 1.0] 0.303

During the follow-up period (1.1.1998 — 31.12.2019), 809 out of 5436 females with L12_NAIL_INGROW died.

Males

Parameter HR [95% CI] p-value
L12_NAIL_INGROW 1.455 [1.26, 1.68] < 0.001
Birth year 0.99 [0.98, 1.0] 0.054

During the follow-up period (1.1.1998 — 31.12.2019), 676 out of 6439 males with L12_NAIL_INGROW died.

Mortality risk

Mortality risk for people of age

years, who have L12_NAIL_INGROW.

N-year risk Females Males
1 0.161% 0.288%
5 0.906% 1.737%
10 2.069% 4.731%
15 4.191% 8.483%
20 7.372% 14.601%

Relationships between endpoints

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Index endpoint: L12_NAIL_INGROW – Ingrowing nail

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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