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Onycholysis

DOID Endpoint Browser PheWeb

L12_NAIL_LYSIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L60.1
  • Hospital discharge: ICD-9 — 7038D
  • Hospital discharge: ICD-8 — 70306
  • Cause of death: ICD-10 — L60.1
  • Cause of death: ICD-9 — 7038D
  • Cause of death: ICD-8 — 70306

2 out of 7 registries used, show all original rules.

198

4. Check minimum number of events

None

198

5. Include endpoints

None

198

6. Filter based on genotype QC (FinnGen only)

192

Control definitions (FinnGen only)

Control exclude L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L60
Name in latin Onycholysis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1667 990 666
Only index persons 1526 920 606
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 44.88 48.31 39.98
Only index persons 46.36 49.26 41.97

-FinnGen-

Key figures

All Female Male
Number of individuals 192 129 63
Unadjusted period prevalence (%) 0.04 0.05 0.03
Median age at first event (years) 53.24 50.45 58.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint L12_NAIL_LYSIS and mortality.

Females

Parameter HR [95% CI] p-value
L12_NAIL_LYSIS 1.582 [1.07, 2.33] 0.02
Birth year 0.995 [0.99, 1.0] 0.282

During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 827 females with L12_NAIL_LYSIS died.

Males

Parameter HR [95% CI] p-value
L12_NAIL_LYSIS 1.692 [1.09, 2.62] 0.018
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 543 males with L12_NAIL_LYSIS died.

Mortality risk

Mortality risk for people of age

years, who have L12_NAIL_LYSIS.

N-year risk Females Males
1 0.189% 0.308%
5 0.914% 1.598%
10 2.268% 4.152%
15 4.445% 7.92%
20 7.88% 13.34%

Relationships between endpoints

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Index endpoint: L12_NAIL_LYSIS – Onycholysis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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