No definition available.
Other disorders of fluid, electrolyte and acid-base balance
EFO MESH Endpoint Browser PheWeb
E4_FLUIDELECTRO
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
12099 |
4. Check minimum number of eventsNone |
12099 |
5. Include endpoints |
12313 |
6. Filter based on genotype QC (FinnGen only) |
11929 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E70-E90
Name in latin
Aliae perturbationes aequilibrii humoralis, electrolytici et acido-alkalici
Other disorders of fluid, electrolyte and acid-base balance
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 135674 | 82514 | 52202 |
| Only index persons | 114174 | 70187 | 43987 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.01 | 2.36 | 1.46 |
| Only index persons | 2.23 | 2.58 | 1.68 |
| Median age at first event (years) | |||
| Whole population | 72.18 | 75.73 | 66.59 |
| Only index persons | 72.02 | 75.45 | 66.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 11929 | 6542 | 5387 |
| Unadjusted period prevalence (%) | 2.63 | 2.57 | 2.71 |
| Median age at first event (years) | 68.49 | 68.42 | 68.57 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_FLUIDELECTRO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FLUIDELECTRO | 2.069 [1.88, 2.28] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.075 |
During the follow-up period (1.1.1998 — 31.12.2019), 30904 out of 62802 females with E4_FLUIDELECTRO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FLUIDELECTRO | 3.843 [3.36, 4.4] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 19521 out of 38323 males with E4_FLUIDELECTRO died.
Mortality risk
Mortality risk for people of age
years, who have E4_FLUIDELECTRO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.214% | 0.689% |
| 5 | 1.134% | 4.028% |
| 10 | 2.629% | 9.432% |
| 15 | 5.084% | 16.832% |
| 20 | 8.733% | 27.242% |
Relationships between endpoints
↥Index endpoint: E4_FLUIDELECTRO – Other disorders of fluid, electrolyte and acid-base balance
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data