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Acidosis

DOID EFO Endpoint Browser PheWeb

E4_ACIDOSIS

lactic acidosis: Metabolic disease characterized by the accumulation of lactate in the body. It is caused by tissue hypoxia

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E87.2
  • Hospital discharge: ICD-9 — 2762
  • Hospital discharge: ICD-8 — 78869
  • Cause of death: ICD-10 — E87.2
  • Cause of death: ICD-9 — 2762
  • Cause of death: ICD-8 — 78869

2 out of 7 registries used, show all original rules.

610

4. Check minimum number of events

None

610

5. Include endpoints

None

610

6. Filter based on genotype QC (FinnGen only)

593

Control definitions (FinnGen only)

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E87
Name in latin Acidosis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5856 2122 3700
Only index persons 5240 1915 3325
Unadjusted period prevalence (%)
Whole population 0.09 0.06 0.10
Only index persons 0.11 0.07 0.13
Median age at first event (years)
Whole population 65.37 68.63 63.47
Only index persons 65.67 68.69 63.92

-FinnGen-

Key figures

All Female Male
Number of individuals 593 211 382
Unadjusted period prevalence (%) 0.15 0.08 0.19
Median age at first event (years) 64.75 63.27 65.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint E4_ACIDOSIS and mortality.

Females

Parameter HR [95% CI] p-value
E4_ACIDOSIS 4.343 [3.3, 5.71] < 0.001
Birth year 0.997 [0.99, 1.01] 0.601

During the follow-up period (1.1.1998 — 31.12.2019), 482 out of 1194 females with E4_ACIDOSIS died.

Males

Parameter HR [95% CI] p-value
E4_ACIDOSIS 5.206 [4.09, 6.63] < 0.001
Birth year 0.988 [0.98, 1.0] 0.012

During the follow-up period (1.1.1998 — 31.12.2019), 864 out of 2128 males with E4_ACIDOSIS died.

Mortality risk

Mortality risk for people of age

years, who have E4_ACIDOSIS.

N-year risk Females Males
1 0.48% 0.771%
5 2.92% 5.339%
10 6.434% 13.916%
15 12.782% 25.455%
20 22.326% 39.972%

Relationships between endpoints

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Index endpoint: E4_ACIDOSIS – Acidosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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