obsolete_hypercalcemia: ['An homeostasis disorder leading to an abnormally increased calcium concentration in the blood.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1847 |
4. Check minimum number of eventsNone |
1847 |
5. Include endpointsNone |
1847 |
6. Filter based on genotype QC (FinnGen only) |
1788 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E87
Name in latin
Hyperkalaemia
Similar endpoints
↥List of similar endpoints to
Hyperkalaemia
based on the number of shared cases.
Similar with more cases:
- Other disorders of fluid, electrolyte and acid-base balance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18429 | 9206 | 9040 |
| Only index persons | 14271 | 7052 | 7219 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.26 | 0.26 | 0.25 |
| Only index persons | 0.27 | 0.26 | 0.28 |
| Median age at first event (years) | |||
| Whole population | 76.34 | 79.83 | 72.83 |
| Only index persons | 76.12 | 79.77 | 72.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1788 | 688 | 1100 |
| Unadjusted period prevalence (%) | 0.44 | 0.27 | 0.55 |
| Median age at first event (years) | 72.40 | 72.94 | 72.07 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERKALAEMIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERKALAEMIA | 3.045 [2.64, 3.51] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.281 |
During the follow-up period (1.1.1998 — 31.12.2019), 4566 out of 6803 females with E4_HYPERKALAEMIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERKALAEMIA | 4.012 [3.31, 4.86] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 4122 out of 6564 males with E4_HYPERKALAEMIA died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPERKALAEMIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.291% | 0.61% |
| 5 | 1.629% | 4.068% |
| 10 | 4.23% | 9.431% |
| 15 | 8.32% | 17.628% |
| 20 | 14.817% | 28.805% |
Relationships between endpoints
↥Index endpoint: E4_HYPERKALAEMIA – Hyperkalaemia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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