≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Alkalosis

DOID EFO Endpoint Browser PheWeb

E4_ALKALOSIS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E87.3
  • Hospital discharge: ICD-9 — 2763
  • Hospital discharge: ICD-8 — 78870
  • Cause of death: ICD-10 — E87.3
  • Cause of death: ICD-9 — 2763
  • Cause of death: ICD-8 — 78870

2 out of 7 registries used, show all original rules.

72

4. Check minimum number of events

None

72

5. Include endpoints

None

72

6. Filter based on genotype QC (FinnGen only)

71

Control definitions (FinnGen only)

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E87
Name in latin Alkalosis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 798 411 378
Only index persons 681 363 318
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 61.60 64.07 58.89
Only index persons 61.83 64.41 58.89

-FinnGen-

Key figures

All Female Male
Number of individuals 71 37 34
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 57.84 54.24 61.75

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

↥

Association

Association between endpoint E4_ALKALOSIS and mortality.

Females

Parameter HR [95% CI] p-value
E4_ALKALOSIS 3.225 [1.93, 5.39] < 0.001
Birth year 0.992 [0.98, 1.0] 0.087

During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 300 females with E4_ALKALOSIS died.

Males

Parameter HR [95% CI] p-value
E4_ALKALOSIS 4.629 [2.28, 9.39] < 0.001
Birth year 0.99 [0.98, 1.0] 0.034

During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 246 males with E4_ALKALOSIS died.

Mortality risk

Mortality risk for people of age

years, who have E4_ALKALOSIS.

N-year risk Females Males
1 0.279% 1.062%
5 1.763% 5.621%
10 4.404% 13.68%
15 8.305% 24.568%
20 13.736% 38.647%

Relationships between endpoints

↥

Index endpoint: E4_ALKALOSIS – Alkalosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data