No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
6435 |
4. Check minimum number of eventsNone |
6435 |
5. Include endpointsNone |
6435 |
6. Filter based on genotype QC (FinnGen only) |
6271 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E87
Name in latin
Hyposmolalitas
Similar endpoints
↥List of similar endpoints to
Hypo-osmolality and hyponatraemia
based on the number of shared cases.
Similar with more cases:
- Other disorders of fluid, electrolyte and acid-base balance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 74063 | 47522 | 26119 |
| Only index persons | 63818 | 41374 | 22444 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.13 | 1.36 | 0.73 |
| Only index persons | 1.29 | 1.52 | 0.86 |
| Median age at first event (years) | |||
| Whole population | 73.12 | 77.26 | 65.64 |
| Only index persons | 73.08 | 77.07 | 65.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6271 | 3603 | 2668 |
| Unadjusted period prevalence (%) | 1.38 | 1.42 | 1.34 |
| Median age at first event (years) | 69.56 | 70.76 | 67.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPOOSMNAT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPOOSMNAT | 1.818 [1.65, 2.01] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.155 |
During the follow-up period (1.1.1998 — 31.12.2019), 18945 out of 38171 females with E4_HYPOOSMNAT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPOOSMNAT | 3.849 [3.34, 4.44] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 10179 out of 20213 males with E4_HYPOOSMNAT died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPOOSMNAT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.202% | 0.881% |
| 5 | 0.978% | 4.201% |
| 10 | 2.405% | 10.121% |
| 15 | 4.636% | 19.417% |
| 20 | 8.313% | 30.311% |
Relationships between endpoints
↥Index endpoint: E4_HYPOOSMNAT – Hypo-osmolality and hyponatraemia
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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