No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
88 |
4. Check minimum number of eventsNone |
88 |
5. Include endpointsNone |
88 |
6. Filter based on genotype QC (FinnGen only) |
87 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E87
Name in latin
Incrementum voluminis liquoris
Similar endpoints
↥List of similar endpoints to
Fluid overload
based on the number of shared cases.
Similar with more cases:
- Other disorders of fluid, electrolyte and acid-base balance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 582 | 293 | 287 |
| Only index persons | 524 | 263 | 261 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 69.82 | 72.88 | 66.78 |
| Only index persons | 69.84 | 72.88 | 66.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 87 | 41 | 46 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 64.18 | 69.79 | 59.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_FLUIDOVER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FLUIDOVER | 3.281 [1.98, 5.44] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.135 |
During the follow-up period (1.1.1998 — 31.12.2019), 103 out of 212 females with E4_FLUIDOVER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_FLUIDOVER | 6.861 [3.77, 12.48] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.098 |
During the follow-up period (1.1.1998 — 31.12.2019), 127 out of 212 males with E4_FLUIDOVER died.
Mortality risk
Mortality risk for people of age
years, who have E4_FLUIDOVER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.229% | 1.763% |
| 5 | 1.508% | 9.368% |
| 10 | 4.476% | 22.161% |
| 15 | 8.006% | 39.888% |
| 20 | 13.834% | 56.64% |
Relationships between endpoints
↥Index endpoint: E4_FLUIDOVER – Fluid overload
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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