No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
424 |
4. Check minimum number of eventsNone |
424 |
5. Include endpointsNone |
424 |
6. Filter based on genotype QC (FinnGen only) |
408 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E87
Name in latin
Hyperosmolalitas
Similar endpoints
↥List of similar endpoints to
Hyperosmolality and hypernatraemia
based on the number of shared cases.
Similar with more cases:
- Other disorders of fluid, electrolyte and acid-base balance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6622 | 3751 | 2831 |
| Only index persons | 5696 | 3249 | 2447 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.11 | 0.08 |
| Only index persons | 0.11 | 0.12 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 77.28 | 80.01 | 73.68 |
| Only index persons | 77.45 | 80.17 | 73.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 408 | 187 | 221 |
| Unadjusted period prevalence (%) | 0.09 | 0.07 | 0.11 |
| Median age at first event (years) | 70.51 | 70.45 | 70.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPEROSMHNAT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPEROSMHNAT | 2.976 [2.48, 3.57] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.197 |
During the follow-up period (1.1.1998 — 31.12.2019), 1646 out of 2715 females with E4_HYPEROSMHNAT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPEROSMHNAT | 4.461 [3.18, 6.26] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 1063 out of 1820 males with E4_HYPEROSMHNAT died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPEROSMHNAT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.292% | 0.98% |
| 5 | 1.729% | 5.517% |
| 10 | 4.226% | 12.168% |
| 15 | 8.068% | 21.54% |
| 20 | 13.518% | 34.209% |
Relationships between endpoints
↥Index endpoint: E4_HYPEROSMHNAT – Hyperosmolality and hypernatraemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data