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Hypokalaemia

DOID EFO Endpoint Browser PheWeb

E4_HYPOKALAEMIA

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E87.6
  • Hospital discharge: ICD-9 — 2768
  • Hospital discharge: ICD-8 — 78891
  • Cause of death: ICD-10 — E87.6
  • Cause of death: ICD-9 — 2768
  • Cause of death: ICD-8 — 78891

2 out of 7 registries used, show all original rules.

4218

4. Check minimum number of events

None

4218

5. Include endpoints

None

4218

6. Filter based on genotype QC (FinnGen only)

4067

Control definitions (FinnGen only)

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E87
Name in latin Hypokalaemia

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 44509 28754 15405
Only index persons 37186 24295 12891
Unadjusted period prevalence (%)
Whole population 0.68 0.82 0.43
Only index persons 0.75 0.89 0.49
Median age at first event (years)
Whole population 68.02 70.70 63.06
Only index persons 67.64 70.04 63.12

-FinnGen-

Key figures

All Female Male
Number of individuals 4067 2539 1528
Unadjusted period prevalence (%) 0.91 1.00 0.77
Median age at first event (years) 64.47 63.31 66.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint E4_HYPOKALAEMIA and mortality.

Females

Parameter HR [95% CI] p-value
E4_HYPOKALAEMIA 2.339 [2.11, 2.59] < 0.001
Birth year 0.997 [0.99, 1.0] 0.411

During the follow-up period (1.1.1998 — 31.12.2019), 8934 out of 20756 females with E4_HYPOKALAEMIA died.

Males

Parameter HR [95% CI] p-value
E4_HYPOKALAEMIA 4.304 [3.73, 4.97] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 5287 out of 11180 males with E4_HYPOKALAEMIA died.

Mortality risk

Mortality risk for people of age

years, who have E4_HYPOKALAEMIA.

N-year risk Females Males
1 0.275% 0.845%
5 1.248% 4.493%
10 3.163% 11.026%
15 6.378% 20.024%
20 11.442% 31.02%

Relationships between endpoints

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Index endpoint: E4_HYPOKALAEMIA – Hypokalaemia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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