hematologic disease: A disease involving the hematopoietic system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
8559 |
6. Filter based on genotype QC (FinnGen only) |
8243 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other diseases of blood and blood-forming organs
based on the number of shared cases.
Similar with more cases:
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 61862 | 33444 | 27962 |
| Only index persons | 52577 | 29034 | 23543 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.87 | 0.96 | 0.78 |
| Only index persons | 0.99 | 1.07 | 0.90 |
| Median age at first event (years) | |||
| Whole population | 59.66 | 59.54 | 59.73 |
| Only index persons | 58.81 | 58.55 | 59.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 8243 | 4649 | 3594 |
| Unadjusted period prevalence (%) | 1.82 | 1.83 | 1.80 |
| Median age at first event (years) | 59.49 | 57.04 | 62.67 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_BLOODOTHER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_BLOODOTHER | 3.195 [2.89, 3.53] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 7704 out of 25972 females with D3_BLOODOTHER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_BLOODOTHER | 3.295 [2.94, 3.69] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 7471 out of 21167 males with D3_BLOODOTHER died.
Mortality risk
Mortality risk for people of age
years, who have D3_BLOODOTHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.244% | 0.68% |
| 5 | 1.523% | 3.577% |
| 10 | 3.825% | 8.513% |
| 15 | 7.013% | 16.125% |
| 20 | 12.503% | 26.374% |
Relationships between endpoints
↥Index endpoint: D3_BLOODOTHER – Other diseases of blood and blood-forming organs
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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