No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
2393 |
4. Check minimum number of eventsNone |
2393 |
5. Include endpointsNone |
2393 |
6. Filter based on genotype QC (FinnGen only) |
2318 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced neutropenia
based on the number of shared cases.
Similar with more cases:
- Agranulocytosis
- Other diseases of blood and blood-forming organs
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12860 | 7872 | 4919 |
| Only index persons | 11777 | 7306 | 4471 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.23 | 0.14 |
| Only index persons | 0.23 | 0.27 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 63.94 | 62.61 | 66.05 |
| Only index persons | 63.92 | 62.58 | 66.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2318 | 1481 | 837 |
| Unadjusted period prevalence (%) | 0.52 | 0.58 | 0.42 |
| Median age at first event (years) | 62.58 | 60.33 | 66.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_NEUTROPENIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_NEUTROPENIA | 8.726 [7.5, 10.15] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.057 |
During the follow-up period (1.1.1998 — 31.12.2019), 2730 out of 6944 females with DRUGADVERS_NEUTROPENIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_NEUTROPENIA | 9.331 [7.49, 11.63] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 2303 out of 4090 males with DRUGADVERS_NEUTROPENIA died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_NEUTROPENIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.721% | 1.851% |
| 5 | 4.66% | 10.622% |
| 10 | 11.24% | 23.446% |
| 15 | 20.101% | 40.366% |
| 20 | 32.103% | 60.541% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_NEUTROPENIA – Drug-induced neutropenia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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