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Agranulocytosis

DOID EFO Endpoint Browser PheWeb

D3_AGRANULOCYTOSIS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D70
  • Hospital discharge: ICD-9 — 2880
  • Hospital discharge: ICD-8 — 2889
  • Cause of death: ICD-10 — D70
  • Cause of death: ICD-9 — 2880
  • Cause of death: ICD-8 — 2889

2 out of 7 registries used, show all original rules.

3963

4. Check minimum number of events

None

3963

5. Include endpoints

None

3963

6. Filter based on genotype QC (FinnGen only)

3823

Control definitions (FinnGen only)

Control exclude D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D70-D77
Name in latin Agranulocytosis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 26750 15948 10643
Only index persons 23160 14088 9072
Unadjusted period prevalence (%)
Whole population 0.39 0.46 0.30
Only index persons 0.45 0.52 0.35
Median age at first event (years)
Whole population 60.55 59.89 61.46
Only index persons 60.52 59.67 61.85

-FinnGen-

Key figures

All Female Male
Number of individuals 3823 2418 1405
Unadjusted period prevalence (%) 0.86 0.95 0.71
Median age at first event (years) 60.82 58.35 65.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint D3_AGRANULOCYTOSIS and mortality.

Females

Parameter HR [95% CI] p-value
D3_AGRANULOCYTOSIS 5.186 [4.61, 5.84] < 0.001
Birth year 0.994 [0.99, 1.0] 0.119

During the follow-up period (1.1.1998 — 31.12.2019), 4363 out of 13068 females with D3_AGRANULOCYTOSIS died.

Males

Parameter HR [95% CI] p-value
D3_AGRANULOCYTOSIS 6.042 [5.14, 7.11] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 3667 out of 8454 males with D3_AGRANULOCYTOSIS died.

Mortality risk

Mortality risk for people of age

years, who have D3_AGRANULOCYTOSIS.

N-year risk Females Males
1 0.429% 1.494%
5 2.62% 7.069%
10 6.879% 16.013%
15 13.128% 28.591%
20 21.795% 45.238%

Relationships between endpoints

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Index endpoint: D3_AGRANULOCYTOSIS – Agranulocytosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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