No definition available.
Other and unspecified disorders of white blood cells
DOID EFO Endpoint Browser PheWeb
D3_WHITEBLOODCELLNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1373 |
4. Check minimum number of eventsNone |
1373 |
5. Include endpointsNone |
1373 |
6. Filter based on genotype QC (FinnGen only) |
1299 |
Control definitions (FinnGen only)
Control exclude
D3_BLOODOTHER
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified disorders of white blood cells
based on the number of shared cases.
Similar with more cases:
- Other disorders of white blood cells
- Other diseases of blood and blood-forming organs
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11640 | 6110 | 5442 |
| Only index persons | 9637 | 5134 | 4503 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.18 | 0.15 |
| Only index persons | 0.18 | 0.19 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 59.46 | 58.68 | 60.22 |
| Only index persons | 57.31 | 56.07 | 58.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1299 | 695 | 604 |
| Unadjusted period prevalence (%) | 0.29 | 0.27 | 0.30 |
| Median age at first event (years) | 56.97 | 52.29 | 62.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_WHITEBLOODCELLNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_WHITEBLOODCELLNAS | 2.642 [2.33, 3.0] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.036 |
During the follow-up period (1.1.1998 — 31.12.2019), 1292 out of 4517 females with D3_WHITEBLOODCELLNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_WHITEBLOODCELLNAS | 2.552 [2.21, 2.94] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 1504 out of 4168 males with D3_WHITEBLOODCELLNAS died.
Mortality risk
Mortality risk for people of age
years, who have D3_WHITEBLOODCELLNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.209% | 0.51% |
| 5 | 1.386% | 2.595% |
| 10 | 3.304% | 6.39% |
| 15 | 6.409% | 12.203% |
| 20 | 10.995% | 20.185% |
Relationships between endpoints
↥Index endpoint: D3_WHITEBLOODCELLNAS – Other and unspecified disorders of white blood cells
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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