Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1782 |
4. Check minimum number of eventsNone |
1782 |
5. Include endpoints |
1886 |
6. Filter based on genotype QC (FinnGen only) |
1789 |
Control definitions (FinnGen only)
Control exclude
D3_BLOODOTHER
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D70-D77
Name in latin
Aliae morbositates leucocytorum
Similar endpoints
↥List of similar endpoints to
Other disorders of white blood cells
based on the number of shared cases.
Similar with more cases:
- Other diseases of blood and blood-forming organs
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 15172 | 7959 | 7095 |
| Only index persons | 12791 | 6804 | 5987 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.21 | 0.23 | 0.20 |
| Only index persons | 0.24 | 0.25 | 0.23 |
| Median age at first event (years) | |||
| Whole population | 58.28 | 57.40 | 59.16 |
| Only index persons | 56.26 | 54.92 | 57.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1789 | 959 | 830 |
| Unadjusted period prevalence (%) | 0.40 | 0.38 | 0.42 |
| Median age at first event (years) | 56.74 | 52.27 | 61.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_OTHERWHITECELL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHERWHITECELL | 2.347 [2.09, 2.64] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.084 |
During the follow-up period (1.1.1998 — 31.12.2019), 1514 out of 5993 females with D3_OTHERWHITECELL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHERWHITECELL | 2.421 [2.12, 2.76] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 1770 out of 5506 males with D3_OTHERWHITECELL died.
Mortality risk
Mortality risk for people of age
years, who have D3_OTHERWHITECELL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.184% | 0.514% |
| 5 | 1.121% | 2.821% |
| 10 | 3.172% | 6.665% |
| 15 | 6.287% | 12.13% |
| 20 | 10.342% | 20.488% |
Relationships between endpoints
↥Index endpoint: D3_OTHERWHITECELL – Other disorders of white blood cells
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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