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Eosinophilia

D3_EOSINOPHILIA

Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D72.1
  • Hospital discharge: ICD-9 2883
  • Cause of death: ICD-10 D72.1
  • Cause of death: ICD-9 2883

2 out of 7 registries used, show all original rules.

503

4. Check minimum number of events

None

503

5. Include endpoints

None

503

6. Filter based on genotype QC (FinnGen only)

480

Control definitions (FinnGen only)

Control exclude D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D72
Name in latin Eosinophilia

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 480 259 221
Unadjusted period prevalence (%) 0.11 0.10 0.11
Median age at first event (years) 56.60 52.37 61.55

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: D3_EOSINOPHILIA – Eosinophilia

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).