Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
503 |
4. Check minimum number of eventsNone |
503 |
5. Include endpointsNone |
503 |
6. Filter based on genotype QC (FinnGen only) |
480 |
Control definitions (FinnGen only)
Control exclude
ASTHMA_EXCL
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D72
Name in latin
Eosinophilia
Similar endpoints
↥List of similar endpoints to
Eosinophilic disease (BM)
based on the number of shared cases.
Similar with more cases:
- Eosinophilia
- Other disorders of white blood cells
- Other diseases of blood and blood-forming organs
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Excluding asthma or asthma-COPD overlap
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3527 | 1843 | 1656 |
| Only index persons | 3164 | 1666 | 1498 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 54.37 | 53.72 | 55.30 |
| Only index persons | 53.92 | 52.99 | 54.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 480 | 259 | 221 |
| Unadjusted period prevalence (%) | 0.11 | 0.10 | 0.11 |
| Median age at first event (years) | 56.60 | 52.37 | 61.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ESOSINOPHIL_DISEASE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ESOSINOPHIL_DISEASE | 1.584 [1.31, 1.92] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.321 |
During the follow-up period (1.1.1998 — 31.12.2019), 216 out of 1475 females with ESOSINOPHIL_DISEASE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ESOSINOPHIL_DISEASE | 1.733 [1.41, 2.13] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 271 out of 1353 males with ESOSINOPHIL_DISEASE died.
Mortality risk
Mortality risk for people of age
years, who have ESOSINOPHIL_DISEASE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.158% | 0.352% |
| 5 | 1.08% | 1.952% |
| 10 | 2.6% | 4.925% |
| 15 | 4.718% | 9.169% |
| 20 | 8.017% | 15.241% |
Relationships between endpoints
↥Index endpoint: ESOSINOPHIL_DISEASE – Eosinophilic disease (BM)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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