hematologic disease: A disease involving the hematopoietic system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2213 |
4. Check minimum number of eventsNone |
2213 |
5. Include endpoints |
2343 |
6. Filter based on genotype QC (FinnGen only) |
2275 |
Control definitions (FinnGen only)
Control exclude
D3_BLOODOTHER
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D70-D77
Name in latin
Alii morbi sanguinis et organorum haematopoeticorum
Similar endpoints
↥List of similar endpoints to
Other diseases of blood and blood-forming organs
based on the number of shared cases.
Similar with more cases:
- Other diseases of blood and blood-forming organs
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17063 | 8307 | 8588 |
| Only index persons | 14250 | 7111 | 7139 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.24 | 0.24 |
| Only index persons | 0.27 | 0.26 | 0.27 |
| Median age at first event (years) | |||
| Whole population | 60.51 | 61.34 | 59.66 |
| Only index persons | 59.31 | 60.14 | 58.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2275 | 1118 | 1157 |
| Unadjusted period prevalence (%) | 0.51 | 0.44 | 0.58 |
| Median age at first event (years) | 59.29 | 57.91 | 60.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_OTHERBLOOD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHERBLOOD | 1.985 [1.78, 2.22] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.293 |
During the follow-up period (1.1.1998 — 31.12.2019), 1658 out of 6103 females with D3_OTHERBLOOD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHERBLOOD | 1.825 [1.62, 2.05] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 1754 out of 6045 males with D3_OTHERBLOOD died.
Mortality risk
Mortality risk for people of age
years, who have D3_OTHERBLOOD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.216% | 0.396% |
| 5 | 1.289% | 2.196% |
| 10 | 3.139% | 5.364% |
| 15 | 5.656% | 9.533% |
| 20 | 10.057% | 16.307% |
Relationships between endpoints
↥Index endpoint: D3_OTHERBLOOD – Other diseases of blood and blood-forming organs
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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