polycythemia: Abnormally high mass or concentration of red blood cells in the blood, either due to an increase in erythropoiesis or a decrease in plasma volume.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
762 |
4. Check minimum number of eventsNone |
762 |
5. Include endpointsNone |
762 |
6. Filter based on genotype QC (FinnGen only) |
735 |
Control definitions (FinnGen only)
Control exclude
D3_BLOODOTHER
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D75
Name in latin
Polycythaemia secundaria
Similar endpoints
↥List of similar endpoints to
Secondary polycythaemia
based on the number of shared cases.
Similar with more cases:
- Other diseases of blood and blood-forming organs
- Other diseases of blood and blood-forming organs
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5793 | 1925 | 3795 |
| Only index persons | 4662 | 1564 | 3098 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.06 | 0.11 |
| Only index persons | 0.10 | 0.06 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 58.75 | 60.79 | 57.65 |
| Only index persons | 57.47 | 60.07 | 56.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 735 | 248 | 487 |
| Unadjusted period prevalence (%) | 0.19 | 0.10 | 0.24 |
| Median age at first event (years) | 58.02 | 56.76 | 58.67 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_SCNDPOLYCYTHAEMIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SCNDPOLYCYTHAEMIA | 2.337 [1.94, 2.81] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.556 |
During the follow-up period (1.1.1998 — 31.12.2019), 330 out of 1298 females with D3_SCNDPOLYCYTHAEMIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SCNDPOLYCYTHAEMIA | 1.929 [1.65, 2.25] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 574 out of 2522 males with D3_SCNDPOLYCYTHAEMIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_SCNDPOLYCYTHAEMIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.314% | 0.369% |
| 5 | 1.509% | 2.132% |
| 10 | 3.477% | 5.162% |
| 15 | 6.641% | 10.023% |
| 20 | 12.368% | 16.089% |
Relationships between endpoints
↥Index endpoint: D3_SCNDPOLYCYTHAEMIA – Secondary polycythaemia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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