No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
167 |
4. Check minimum number of eventsNone |
167 |
5. Include endpointsNone |
167 |
6. Filter based on genotype QC (FinnGen only) |
162 |
Control definitions (FinnGen only)
Control exclude
D3_BLOODOTHER
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D75
Name in latin
Erythrocytosis familialis
Similar endpoints
↥List of similar endpoints to
Familial erythrocytosis
based on the number of shared cases.
Similar with more cases:
- Other diseases of blood and blood-forming organs
- Other diseases of blood and blood-forming organs
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1157 | 448 | 700 |
| Only index persons | 1033 | 383 | 650 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 56.72 | 59.64 | 54.64 |
| Only index persons | 55.02 | 57.68 | 53.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 162 | 65 | 97 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | 57.30 | 58.46 | 56.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint D3_FAMIERYTHROCYTOCIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_FAMIERYTHROCYTOCIS | 2.131 [1.65, 2.76] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.091 |
During the follow-up period (1.1.1998 — 31.12.2019), 121 out of 403 females with D3_FAMIERYTHROCYTOCIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_FAMIERYTHROCYTOCIS | 1.315 [1.05, 1.65] | 0.018 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 131 out of 643 males with D3_FAMIERYTHROCYTOCIS died.
Mortality risk
Mortality risk for people of age
years, who have D3_FAMIERYTHROCYTOCIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.197% | 0.228% |
| 5 | 1.084% | 1.671% |
| 10 | 2.786% | 4.14% |
| 15 | 5.386% | 7.803% |
| 20 | 9.707% | 13.227% |
Relationships between endpoints
↥Index endpoint: D3_FAMIERYTHROCYTOCIS – Familial erythrocytosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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