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Other and unspecified diseases of blood and blood-forming organs

DOID EFO Endpoint Browser PheWeb

D3_BLOODNAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D75.8, D75.9
  • Hospital discharge: ICD-9 — 289[8-9]
  • Hospital discharge: ICD-8 — 2899
  • Hospital discharge: excluded ICD-8 — 2899[0-1]
  • Cause of death: ICD-10 — D75.8, D75.9
  • Cause of death: ICD-9 — 289[8-9]
  • Cause of death: ICD-8 — 2899
  • Cause of death: excluded ICD-8 — 2899[0-1]

2 out of 7 registries used, show all original rules.

806

4. Check minimum number of events

None

806

5. Include endpoints

None

806

6. Filter based on genotype QC (FinnGen only)

783

Control definitions (FinnGen only)

Control exclude D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6321 3318 2939
Only index persons 5103 2725 2378
Unadjusted period prevalence (%)
Whole population 0.09 0.10 0.08
Only index persons 0.10 0.10 0.09
Median age at first event (years)
Whole population 59.07 58.15 60.11
Only index persons 57.37 55.93 59.01

-FinnGen-

Key figures

All Female Male
Number of individuals 783 413 370
Unadjusted period prevalence (%) 0.17 0.16 0.19
Median age at first event (years) 59.24 57.62 61.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint D3_BLOODNAS and mortality.

Females

Parameter HR [95% CI] p-value
D3_BLOODNAS 2.238 [1.91, 2.63] < 0.001
Birth year 0.995 [0.99, 1.0] 0.245

During the follow-up period (1.1.1998 — 31.12.2019), 570 out of 2131 females with D3_BLOODNAS died.

Males

Parameter HR [95% CI] p-value
D3_BLOODNAS 2.256 [1.9, 2.67] < 0.001
Birth year 0.981 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 665 out of 1883 males with D3_BLOODNAS died.

Mortality risk

Mortality risk for people of age

years, who have D3_BLOODNAS.

N-year risk Females Males
1 0.227% 0.362%
5 1.374% 2.281%
10 3.61% 5.483%
15 6.907% 9.997%
20 11.592% 16.14%

Relationships between endpoints

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Index endpoint: D3_BLOODNAS – Other and unspecified diseases of blood and blood-forming organs

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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