hematologic disease: A disease involving the hematopoietic system.
Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue
DOID EFO Endpoint Browser PheWeb
D3_OTHDISLYMPHORETANDRETICULOHIST
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
104 |
4. Check minimum number of eventsNone |
104 |
5. Include endpoints |
104 |
6. Filter based on genotype QC (FinnGen only) |
99 |
Control definitions (FinnGen only)
Control exclude
D3_BLOODOTHER
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D70-D77
Name in latin
Aliqui morbi textus lymphoreticularis et systematis reticulohistiocytici
Similar endpoints
↥List of similar endpoints to
Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue
based on the number of shared cases.
Similar with more cases:
- Other diseases of blood and blood-forming organs
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 896 | 420 | 473 |
| Only index persons | 719 | 332 | 387 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 34.32 | 35.37 | 33.34 |
| Only index persons | 41.02 | 42.89 | 39.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 99 | 46 | 53 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | 52.20 | 53.10 | 51.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint D3_OTHDISLYMPHORETANDRETICULOHIST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHDISLYMPHORETANDRETICULOHIST | 4.294 [2.6, 7.1] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.683 |
During the follow-up period (1.1.1998 — 31.12.2019), 66 out of 345 females with D3_OTHDISLYMPHORETANDRETICULOHIST died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_OTHDISLYMPHORETANDRETICULOHIST | 3.517 [2.18, 5.68] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 367 males with D3_OTHDISLYMPHORETANDRETICULOHIST died.
Mortality risk
Mortality risk for people of age
years, who have D3_OTHDISLYMPHORETANDRETICULOHIST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.342% | 0.823% |
| 5 | 2.472% | 4.244% |
| 10 | 5.771% | 10.339% |
| 15 | 11.403% | 19.136% |
| 20 | 20.89% | 30.915% |
Relationships between endpoints
↥Index endpoint: D3_OTHDISLYMPHORETANDRETICULOHIST – Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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