splenic disease: A disease involving the spleen.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
531 |
4. Check minimum number of eventsNone |
531 |
5. Include endpoints |
547 |
6. Filter based on genotype QC (FinnGen only) |
526 |
Control definitions (FinnGen only)
Control exclude
D3_BLOODOTHER
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D70-D77
Name in latin
Morbi lienis
Similar endpoints
↥List of similar endpoints to
Diseases of spleen
based on the number of shared cases.
Similar with more cases:
- Other diseases of blood and blood-forming organs
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4031 | 1960 | 2041 |
| Only index persons | 3439 | 1713 | 1726 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.06 | 0.06 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 59.75 | 60.79 | 58.66 |
| Only index persons | 58.74 | 59.31 | 58.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 526 | 262 | 264 |
| Unadjusted period prevalence (%) | 0.12 | 0.10 | 0.13 |
| Median age at first event (years) | 61.33 | 58.02 | 64.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_SPLEENDISEASE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SPLEENDISEASE | 3.971 [3.07, 5.14] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.19 |
During the follow-up period (1.1.1998 — 31.12.2019), 415 out of 1386 females with D3_SPLEENDISEASE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_SPLEENDISEASE | 3.698 [2.92, 4.68] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 499 out of 1462 males with D3_SPLEENDISEASE died.
Mortality risk
Mortality risk for people of age
years, who have D3_SPLEENDISEASE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.481% | 0.759% |
| 5 | 2.249% | 4.089% |
| 10 | 5.579% | 10.28% |
| 15 | 10.302% | 19.424% |
| 20 | 17.274% | 31.076% |
Relationships between endpoints
↥Index endpoint: D3_SPLEENDISEASE – Diseases of spleen
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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