hypersplenism: Overactive functioning of the spleen, resulting in excessive destruction of blood cells.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
132 |
4. Check minimum number of eventsNone |
132 |
5. Include endpointsNone |
132 |
6. Filter based on genotype QC (FinnGen only) |
129 |
Control definitions (FinnGen only)
Control exclude
D3_BLOODOTHER
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D73
Name in latin
Hypersplenismus
Similar endpoints
↥List of similar endpoints to
Hypersplenism
based on the number of shared cases.
Similar with more cases:
- Diseases of spleen
- Other diseases of blood and blood-forming organs
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1082 | 469 | 602 |
| Only index persons | 882 | 381 | 501 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 58.66 | 59.57 | 57.67 |
| Only index persons | 56.73 | 57.62 | 56.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 129 | 57 | 72 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 58.48 | 56.66 | 59.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint D3_HYPERSPLENISM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HYPERSPLENISM | 6.062 [3.72, 9.87] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.274 |
During the follow-up period (1.1.1998 — 31.12.2019), 136 out of 361 females with D3_HYPERSPLENISM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HYPERSPLENISM | 4.648 [3.31, 6.52] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 174 out of 469 males with D3_HYPERSPLENISM died.
Mortality risk
Mortality risk for people of age
years, who have D3_HYPERSPLENISM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.658% | 0.829% |
| 5 | 3.469% | 5.303% |
| 10 | 8.399% | 13.102% |
| 15 | 16.608% | 22.798% |
| 20 | 27.309% | 36.245% |
Relationships between endpoints
↥Index endpoint: D3_HYPERSPLENISM – Hypersplenism
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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