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Other and unspecified diseases of spleen

DOID EFO Endpoint Browser PheWeb

D3_SPLEENNAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D73.8, D73.9
  • Hospital discharge: ICD-9 — 2895A
  • Hospital discharge: ICD-8 — 2894
  • Hospital discharge: excluded ICD-8 — 28940|28942
  • Cause of death: ICD-10 — D73.8, D73.9
  • Cause of death: ICD-9 — 2895A
  • Cause of death: ICD-8 — 2894
  • Cause of death: excluded ICD-8 — 28940|28942

2 out of 7 registries used, show all original rules.

132

4. Check minimum number of events

None

132

5. Include endpoints

None

132

6. Filter based on genotype QC (FinnGen only)

124

Control definitions (FinnGen only)

Control exclude D3_BLOODOTHER

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 905 489 409
Only index persons 758 427 331
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.02 0.01
Median age at first event (years)
Whole population 58.59 60.01 56.88
Only index persons 56.10 56.89 55.07

-FinnGen-

Key figures

All Female Male
Number of individuals 124 64 60
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 58.18 57.02 59.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint D3_SPLEENNAS and mortality.

Females

Parameter HR [95% CI] p-value
D3_SPLEENNAS 3.05 [2.07, 4.49] < 0.001
Birth year 0.994 [0.99, 1.0] 0.19

During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 308 females with D3_SPLEENNAS died.

Males

Parameter HR [95% CI] p-value
D3_SPLEENNAS 2.705 [1.59, 4.59] < 0.001
Birth year 0.989 [0.98, 1.0] 0.017

During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 259 males with D3_SPLEENNAS died.

Mortality risk

Mortality risk for people of age

years, who have D3_SPLEENNAS.

N-year risk Females Males
1 0.325% 0.504%
5 1.613% 2.996%
10 4.027% 8.117%
15 7.92% 15.309%
20 13.948% 25.008%

Relationships between endpoints

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Index endpoint: D3_SPLEENNAS – Other and unspecified diseases of spleen

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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