splenic infarction: Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis. (From Stedman, 25th ed)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
173 |
4. Check minimum number of eventsNone |
173 |
5. Include endpointsNone |
173 |
6. Filter based on genotype QC (FinnGen only) |
168 |
Control definitions (FinnGen only)
Control exclude
D3_BLOODOTHER
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D73
Name in latin
Infarctus lienis
Similar endpoints
↥List of similar endpoints to
Infarction of spleen
based on the number of shared cases.
Similar with more cases:
- Diseases of spleen
- Other diseases of blood and blood-forming organs
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1148 | 520 | 622 |
| Only index persons | 1015 | 470 | 545 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 67.93 | 70.81 | 65.47 |
| Only index persons | 67.43 | 70.42 | 64.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 168 | 75 | 93 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | 69.10 | 69.11 | 69.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint D3_INFARCTSPLEEN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_INFARCTSPLEEN | 4.274 [2.49, 7.33] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.268 |
During the follow-up period (1.1.1998 — 31.12.2019), 141 out of 337 females with D3_INFARCTSPLEEN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_INFARCTSPLEEN | 3.945 [2.59, 6.01] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 157 out of 407 males with D3_INFARCTSPLEEN died.
Mortality risk
Mortality risk for people of age
years, who have D3_INFARCTSPLEEN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.375% | 0.58% |
| 5 | 2.654% | 3.864% |
| 10 | 6.187% | 9.639% |
| 15 | 12.077% | 17.816% |
| 20 | 20.399% | 28.01% |
Relationships between endpoints
↥Index endpoint: D3_INFARCTSPLEEN – Infarction of spleen
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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