Pelvic Inflammatory Disease: Pelvic inflammatory disease (PID) is an acute or chronic inflammation in the pelvic cavity. It is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion. PID may be either symptomatic or asymptomatic. It may cause infertility and it may raise the risk of ectopic pregnancy. PID is a disease associated with HIV infection.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
20100 |
4. Check minimum number of eventsNone |
20100 |
5. Include endpoints |
29354 |
6. Filter based on genotype QC (FinnGen only) |
28179 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Inflammatory diseases of female pelvic organs
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 221084 | 221084 | - |
| Only index persons | 207519 | 207519 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 6.33 | 6.33 | - |
| Only index persons | 7.63 | 7.63 | - |
| Median age at first event (years) | |||
| Whole population | - | 33.84 | - |
| Only index persons | - | 33.41 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 28179 | 28179 | - |
| Unadjusted period prevalence (%) | 11.07 | 11.07 | - |
| Median age at first event (years) | 34.21 | 34.21 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_FEMALEGENINF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_FEMALEGENINF | 1.253 [1.13, 1.39] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.165 |
During the follow-up period (1.1.1998 — 31.12.2019), 5629 out of 106835 females with N14_FEMALEGENINF died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have N14_FEMALEGENINF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.109% | No data |
| 5 | 0.727% | No data |
| 10 | 1.864% | No data |
| 15 | 3.57% | No data |
| 20 | 6.135% | No data |
Relationships between endpoints
↥Index endpoint: N14_FEMALEGENINF – Inflammatory diseases of female pelvic organs
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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