Vulvovaginal ulceration/inflammation in other diseases

N14_VULVOVAGINFINOTH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N77*
  • Cause of death: ICD-10 N77*

2 out of 7 registries used, show all original rules.

2132

4. Check minimum number of events

None

2132

5. Include endpoints

None

2132

6. Filter based on genotype QC (FinnGen only)

2048

Control definitions (FinnGen only)

Control exclude N14_FEMALEGENINF

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13884 13884 -
Only index persons 13459 13459 -
Unadjusted period prevalence (%)
Whole population 0.40 0.40 -
Only index persons 0.49 0.49 -
Median age at first event (years)
Whole population - 30.72 -
Only index persons - 30.83 -

-FinnGen-

Key figures

All Female Male
Number of individuals 2048 2048 -
Unadjusted period prevalence (%) 0.80 0.80 -
Median age at first event (years) 35.58 35.58 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint N14_VULVOVAGINFINOTH and mortality.

Females

Parameter HR [95% CI] p-value
N14_VULVOVAGINFINOTH 1.303 [1.09, 1.56] 0.004
Birth year 0.996 [0.99, 1.0] 0.405

During the follow-up period (1.1.1998 — 31.12.2019), 476 out of 10556 females with N14_VULVOVAGINFINOTH died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_VULVOVAGINFINOTH.

N-year risk Females Males
1 0.112% No data
5 0.75% No data
10 1.751% No data
15 3.739% No data
20 6.78% No data

Relationships between endpoints

Index endpoint: N14_VULVOVAGINFINOTH – Vulvovaginal ulceration/inflammation in other diseases

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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