Other female pelvic inflammatory diseases

N14_OTHFEMPELINF

Pelvic Inflammatory Disease: Pelvic inflammatory disease (PID) is an acute or chronic inflammation in the pelvic cavity. It is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion. PID may be either symptomatic or asymptomatic. It may cause infertility and it may raise the risk of ectopic pregnancy. PID is a disease associated with HIV infection.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N73
  • Hospital discharge: ICD-9 614[3-9]
  • Hospital discharge: ICD-8 616
  • Cause of death: ICD-10 N73
  • Cause of death: ICD-9 614[3-9]
  • Cause of death: ICD-8 616

2 out of 7 registries used, show all original rules.

6440

4. Check minimum number of events

None

6440

5. Include endpoints

None

6440

6. Filter based on genotype QC (FinnGen only)

6181

Control definitions (FinnGen only)

Control exclude N14_FEMALEGENINF

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N70-N77
Name in latin Alii morbi inflammatorii organorum femininorum intrapelvinorum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 46706 46706 -
Only index persons 44208 44208 -
Unadjusted period prevalence (%)
Whole population 1.34 1.34 -
Only index persons 1.63 1.63 -
Median age at first event (years)
Whole population - 36.72 -
Only index persons - 36.35 -

-FinnGen-

Key figures

All Female Male
Number of individuals 6181 6181 -
Unadjusted period prevalence (%) 2.43 2.43 -
Median age at first event (years) 36.08 36.08 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint N14_OTHFEMPELINF and mortality.

Females

Parameter HR [95% CI] p-value
N14_OTHFEMPELINF 1.235 [1.1, 1.39] < 0.001
Birth year 0.995 [0.99, 1.0] 0.208

During the follow-up period (1.1.1998 — 31.12.2019), 840 out of 19663 females with N14_OTHFEMPELINF died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_OTHFEMPELINF.

N-year risk Females Males
1 0.161% No data
5 0.799% No data
10 1.96% No data
15 3.493% No data
20 6.028% No data

Relationships between endpoints

Index endpoint: N14_OTHFEMPELINF – Other female pelvic inflammatory diseases

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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