anus disease: A non-neoplastic or neoplastic disorder that affects the anal canal or anal margin. Representative examples of non-neoplastic disorders include hemorrhoids and anal ulcer. Representative examples of neoplastic disorders include carcinoma, lymphoma, and melanoma. [database_cross_reference: NCIT:C26695]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
772 |
4. Check minimum number of eventsNone |
772 |
5. Include endpointsNone |
772 |
6. Filter based on genotype QC (FinnGen only) |
741 |
Control definitions (FinnGen only)
Control exclude
N14_FEMALEGENINF
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Ulcer of vagina/vulva
based on the number of shared cases.
Similar with more cases:
- Inflammatory diseases of female pelvic organs
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5605 | 5605 | - |
| Only index persons | 5168 | 5168 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.16 | - |
| Only index persons | 0.19 | 0.19 | - |
| Median age at first event (years) | |||
| Whole population | - | 46.23 | - |
| Only index persons | - | 48.21 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 741 | 741 | - |
| Unadjusted period prevalence (%) | 0.29 | 0.29 | - |
| Median age at first event (years) | 50.87 | 50.87 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_ULCERVAGVUL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_ULCERVAGVUL | 1.353 [1.16, 1.58] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.025 |
During the follow-up period (1.1.1998 — 31.12.2019), 484 out of 4215 females with N14_ULCERVAGVUL died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have N14_ULCERVAGVUL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.134% | No data |
| 5 | 0.701% | No data |
| 10 | 1.616% | No data |
| 15 | 3.088% | No data |
| 20 | 5.684% | No data |
Relationships between endpoints
↥Index endpoint: N14_ULCERVAGVUL – Ulcer of vagina/vulva
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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