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Other inflammation of vagina/vulva

DOID EFO Endpoint Browser PheWeb

N14_OTHINFVAGVULV

vaginal inflammation: ['local accumulation of fluid, plasma proteins, and leukocytes in the vagina']

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — N76.8
  • Hospital discharge: ICD-9 — 616[8-9]
  • Hospital discharge: ICD-8 — 6221[8-9]
  • Cause of death: ICD-10 — N76.8
  • Cause of death: ICD-9 — 616[8-9]
  • Cause of death: ICD-8 — 6221[8-9]

2 out of 7 registries used, show all original rules.

1311

4. Check minimum number of events

None

1311

5. Include endpoints

None

1311

6. Filter based on genotype QC (FinnGen only)

1255

Control definitions (FinnGen only)

Control exclude N14_FEMALEGENINF

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N76
Name in latin Aliae inflammationes vaginae et vulvae specificatae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10096 10096 -
Only index persons 9376 9376 -
Unadjusted period prevalence (%)
Whole population 0.29 0.29 -
Only index persons 0.34 0.34 -
Median age at first event (years)
Whole population - 29.59 -
Only index persons - 29.16 -

-FinnGen-

Key figures

All Female Male
Number of individuals 1255 1255 -
Unadjusted period prevalence (%) 0.49 0.49 -
Median age at first event (years) 31.94 31.94 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint N14_OTHINFVAGVULV and mortality.

Females

Parameter HR [95% CI] p-value
N14_OTHINFVAGVULV 1.467 [1.21, 1.78] < 0.001
Birth year 0.99 [0.98, 1.0] 0.034

During the follow-up period (1.1.1998 — 31.12.2019), 234 out of 7600 females with N14_OTHINFVAGVULV died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_OTHINFVAGVULV.

N-year risk Females Males
1 0.11% No data
5 0.77% No data
10 1.954% No data
15 3.514% No data
20 6.153% No data

Relationships between endpoints

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Index endpoint: N14_OTHINFVAGVULV – Other inflammation of vagina/vulva

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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