myositis: An inflammatory disease involving a pathogenic inflammatory response in the muscle tissue.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3282 |
4. Check minimum number of eventsNone |
3282 |
5. Include endpoints |
3948 |
6. Filter based on genotype QC (FinnGen only) |
3790 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Disorders of muscles
based on the number of shared cases.
Similar with more cases:
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 35104 | 16282 | 18568 |
| Only index persons | 31565 | 14997 | 16568 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.49 | 0.47 | 0.52 |
| Only index persons | 0.59 | 0.55 | 0.63 |
| Median age at first event (years) | |||
| Whole population | 45.67 | 48.04 | 43.54 |
| Only index persons | 44.75 | 47.23 | 42.51 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3790 | 2041 | 1749 |
| Unadjusted period prevalence (%) | 0.84 | 0.80 | 0.88 |
| Median age at first event (years) | 50.62 | 47.90 | 53.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_MUSCLE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MUSCLE | 1.539 [1.37, 1.73] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 1526 out of 11080 females with M13_MUSCLE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_MUSCLE | 1.437 [1.28, 1.62] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 1845 out of 11972 males with M13_MUSCLE died.
Mortality risk
Mortality risk for people of age
years, who have M13_MUSCLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.11% | 0.275% |
| 5 | 0.822% | 1.707% |
| 10 | 1.869% | 4.159% |
| 15 | 3.408% | 7.771% |
| 20 | 5.756% | 13.475% |
Relationships between endpoints
↥Index endpoint: M13_MUSCLE – Disorders of muscles
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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