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Myositis

DOID EFO Endpoint Browser PheWeb

M13_MYOSITIS

myositis: An inflammatory disease involving a pathogenic inflammatory response in the muscle tissue.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M60
  • Hospital discharge: ICD-9 — 7280
  • Hospital discharge: ICD-8 — 732
  • Cause of death: ICD-10 — M60
  • Cause of death: ICD-9 — 7280
  • Cause of death: ICD-8 — 732

2 out of 7 registries used, show all original rules.

876

4. Check minimum number of events

None

876

5. Include endpoints

None

876

6. Filter based on genotype QC (FinnGen only)

837

Control definitions (FinnGen only)

Control exclude M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M60-M63
Name in latin Myositis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7204 3423 3738
Only index persons 6302 3063 3239
Unadjusted period prevalence (%)
Whole population 0.10 0.10 0.10
Only index persons 0.12 0.11 0.12
Median age at first event (years)
Whole population 49.20 52.96 45.69
Only index persons 48.87 52.23 45.69

-FinnGen-

Key figures

All Female Male
Number of individuals 837 435 402
Unadjusted period prevalence (%) 0.19 0.17 0.20
Median age at first event (years) 55.93 52.93 59.19

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint M13_MYOSITIS and mortality.

Females

Parameter HR [95% CI] p-value
M13_MYOSITIS 1.699 [1.49, 1.94] < 0.001
Birth year 0.995 [0.99, 1.0] 0.236

During the follow-up period (1.1.1998 — 31.12.2019), 503 out of 2586 females with M13_MYOSITIS died.

Males

Parameter HR [95% CI] p-value
M13_MYOSITIS 1.774 [1.52, 2.07] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 567 out of 2795 males with M13_MYOSITIS died.

Mortality risk

Mortality risk for people of age

years, who have M13_MYOSITIS.

N-year risk Females Males
1 0.163% 0.313%
5 0.885% 2.16%
10 2.391% 5.604%
15 4.697% 10.214%
20 8.407% 16.702%

Relationships between endpoints

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Index endpoint: M13_MYOSITIS – Myositis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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