muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
198 |
4. Check minimum number of eventsNone |
198 |
5. Include endpointsNone |
198 |
6. Filter based on genotype QC (FinnGen only) |
185 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M62
Name in latin
Ruptura musculi non traumatica
Similar endpoints
↥List of similar endpoints to
Other rupture of muscle
based on the number of shared cases.
Similar with more cases:
- Disorders of muscles
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1604 | 713 | 883 |
| Only index persons | 1502 | 672 | 830 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 53.09 | 53.57 | 52.63 |
| Only index persons | 52.22 | 52.43 | 52.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 185 | 93 | 92 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.05 |
| Median age at first event (years) | 55.54 | 51.84 | 59.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_RUPTUREMUSC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_RUPTUREMUSC | 1.322 [1.05, 1.67] | 0.019 |
| Birth year | 0.999 [0.99, 1.01] | 0.778 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 564 females with M13_RUPTUREMUSC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_RUPTUREMUSC | 1.218 [1.01, 1.46] | 0.036 |
| Birth year | 0.992 [0.98, 1.0] | 0.09 |
During the follow-up period (1.1.1998 — 31.12.2019), 150 out of 748 males with M13_RUPTUREMUSC died.
Mortality risk
Mortality risk for people of age
years, who have M13_RUPTUREMUSC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.121% | 0.238% |
| 5 | 0.7% | 1.591% |
| 10 | 1.947% | 4.175% |
| 15 | 4.052% | 7.574% |
| 20 | 7.25% | 13.317% |
Relationships between endpoints
↥Index endpoint: M13_RUPTUREMUSC – Other rupture of muscle
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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